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Substance P — Datasheet

CAT. NO. DC10663

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ParameterValue
Chemical NameSubstance P
CAS No.33507-63-0
SynonymsSubstance P;H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;Aminophenylacetylleucine;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;D-phenylglycyl-L-leucine;H-RPKPQQFFGLM-NH2;Neurokinin P;neuropeptide substance P;R-Phg-S-Leu;RPKPQQFFGLM;RPKPQQFFGLM-NH2;Sh-oligopeptide-73;GTPL3805;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(Substance P);Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-amine;(SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;CHEBI:80308;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;[3H]-substance P;ADNPLDHMAVUMIW-CUZNLEPHSA-N;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(substance P);Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2);RPKPQQFFGLM (modifications: C-terminal amide);H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-D-Phe-Gly-Leu-Met-NH2;BDBM50001450;tachykinin substance P (SP);SCHEMBL1116347;SCHEMBL20844802;HB2915;C63H98N18O13S;UNII-675VGV5J1D;Neurokinin P TFA;Substance p (1-11);12769-48-1;ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O;Neurokinin PNeurokinin P;GTPL3835;Substanz-P;33507-63-0;[125I]-substance P;[3H]SP (human, mouse, rat);[3H]-SP;GTPL2098;Neurokinin-1;ArgProLysProGlnGlnPhePheGlyLeuMet;AS-77493;EINECS 251-545-8;CCRIS 7229;[125I]SP (human, mouse, rat);AKOS024456424;NCGC00167123-01;Q411041;[125I]-SP;NS00074307;Neuropeptide sp-1;substance-P;11035-08-8;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2;675VGV5J1D;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.(Substance P);CHEMBL235363
FormulaC63H98N18O13S
M.Wt1347.63002
SMILESCC(C[C@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H]2CCCN2C([C@@H](N)CCCNC(N)=N)=O)=O)CCCCN)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)C(N[C@H](C(N)=O)CCSC)=O)C
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.

In Vitro

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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