DC Chemicals · Product datasheet

CBL0137 — Datasheet

CAT. NO. DC10617

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ParameterValue
Chemical NameCBL 0137
CAS No.1197996-80-7
Synonyms1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone;1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone;AK126635;CBL-0137 free base;KB-216069;SureCN2361265;UNII-8XKR07H9ER;8XKR07H9ER;EX-A4237;CHEMBL4640631;Ethanone, 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]bis-;1,1'-{9-[2-(Isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone;JKCSODVERGVDLT-UHFFFAOYSA-N;BCP29977;cbl0137;NSC-789040;CS-0014629;Curaxin-137;CBL-0137;Curaxin 137;1-[6-acetyl-9-[2-(isopropylamino)ethyl]carbazol-3-yl]ethanone;1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone;TS-08988;HY-18935;1,1'-(9-(2-(isopropylamino)ethyl)-9H-carbazole-3,6-diyl)bis(ethan-1-one);BC165662;F78005;NSC789040;BDBM50544058;CHEBI:138650;3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole;CBL 0137;SB17204;CBL 137; Curaxin 137;SCHEMBL2361265;DTXSID10152589;CBL-0137; CBL 0137; Curaxin 137;AKOS016012947;Q27271162;1197996-80-7
FormulaC21H24N2O2
M.Wt336.42746
SMILESCC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. 11690) in preclinical models of pancreatic cancer.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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