DC Chemicals · Product datasheet

RX518(CK-101:EGFR-IN-3) — Datasheet

CAT. NO. DC10479

Product page and current package options

ParameterValue
Chemical NameN-[3-[2-[[2,3-difluoro-4-[4-(2-hydroxyethyl)-1-piperazinyl]phenyl]amino]-8-quinazolinyl]phenyl]-2-Propenamide
CAS No.1660963-42-7
SynonymsCK101,CK-101,CK 101,RX518,RX-518,RX 518
FormulaC29H28F2N6O2
M.Wt530.6
SMILESC1CN(CCO)CCN1C1=C(F)C(F)=C(NC2=NC3C(C4=CC(NC(C=C)=O)=CC=C4)=CC=CC=3C=N2)C=C1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

RX518(CK-101:EGFR-IN-3) is an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations, including the resistance mutation T790M, and the L858R and exon 19 deletion (del 19) mutations, with potential antineoplastic activity.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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