DC Chemicals · Product datasheet

Autophinib — Datasheet

CAT. NO. DC10461

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ParameterValue
Chemical NameAutophinib
CAS No.1644443-47-9
SynonymsAutophinib;6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine;6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine;BCP25844;BDBM50543600;s8596;ZB1499
FormulaC14H11ClN6O3
M.Wt346.7285
SMILESClC1C([H])=C(N=C(N=1)OC1C([H])=C([H])C(=C([H])C=1[H])[N+](=O)[O-])N([H])C1C([H])=C(C([H])([H])[H])N([H])N=1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Autophinib is a potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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