DC Chemicals · Product datasheet

Iberdomide — Datasheet

CAT. NO. DC10174

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ParameterValue
Chemical NameIberdomide
CAS No.1323403-33-3
SynonymsIberdomide;CC 220;CC-220;CC220;8V66F27X44;(S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(3s)-3-[4-({4-[(Morpholin-4-Yl)methyl]phenyl}methoxy)-1-Oxo-1,3-Dihydro-2h-Isoindol-2-Yl]piperidine-2,6-Dione;Iberdomide [USAN];Iberdomide (USAN/INN);GTPL9618;BDBM65497;IXZOHGPZAQLIBH-NRFANRHFSA-N;BCP20299;compound 6 [PMID: 28425720];SB18830;DB12101;D111
FormulaC25H27N3O5
M.Wt449.4990
SMILESO(C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2C(N(C([H])([H])C=21)[C@]1([H])C(N([H])C(C([H])([H])C1([H])[H])=O)=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM.

In Vitro

Lenalidomide and pomalidomide, targeting cereblon, are immunomodulatory drugs that are clinically effective in the treatment of cancer, including newly diagnosed and relapsed multiple myeloma. Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM [1].

In Vivo

Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM)[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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