DC Chemicals · Product datasheet

JD5037 — Datasheet

CAT. NO. DC10095

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ParameterValue
Chemical NameButanamide, 2-((((4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl)(((4-chlorophenyl)sulfonyl)amino)methylene)amino)-3-methyl-, (2S)-
CAS No.1392116-14-1
SynonymsJD-5037;JD 5037;JD5037;ENZ75DG2Z6;(S)-2-(((E)-((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)((4-chlorophenyl)sulfonamido)methylene)amino)-3-methylbutanamide;GTPL10690;BDBM286106;(2S)-2-[[[(4S)-5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-[(4-chlorophenyl)sulfonylamino]methylidene]amino]-3-methylbutanamide;BCP23654;BDBM50392283;s6735;JD 5037;JD5037;HY-;Butanamide, 2-((((4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl)(((4-chlorophenyl)sulf
FormulaC27H27Cl2N5O3S
M.Wt572.506
SMILESClC1C([H])=C([H])C(=C([H])C=1[H])C1[C@@]([H])(C2C([H])=C([H])C([H])=C([H])C=2[H])C([H])([H])N(/C(/N([H])S(C2C([H])=C([H])C(=C([H])C=2[H])Cl)(=O)=O)=N\[C@]([H])(C(N([H])[H])=O)C([H])(C([H])([H])[H])C([H])([H])[H])N=1
Purity>95%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia, and reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice[2]. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice[3].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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