Product imageResearch use only

CAT. NO. DCL0004Featured

LC-1

Ionizable Lipids for Gene Editing · RNA delivery · brain-targeted delivery · cationic/ionizable lipids · gene-editing delivery

Research highlights

Large RNA cargo: screened using 5.7-kb ABE–NanoLuc mRNA. Mouse liver: 79.1% edited hepatocytes after intravenous delivery of Cas9 mRNA and sgRNA. Mouse brain: 48.3% edited neurons after intrathecal delivery. Mouse lung: 27% Cas9-mediated editing reported after intratracheal delivery.

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Product overview

Description & Application

LC-1 (LC-lipid-1) is an ionizable lipid identified by screening a 384-member Ugi-reaction library with a large, 5.7-kb ABE–NanoLuc mRNA cargo. The cited study evaluated LC-1 lipid nanoparticles for delivery of Cas9 and base-editing cargos to the liver, brain and lung in mice, using different formulations and administration routes.

CAS No.	Not available
Chemical Name	LC-1
SMILES	CCCCCCCCCCCCCC(=O)N(CCCN1CCCC1)C(C(C)(C)C)C(=O)NCCCCCCOC(=O)C(CCCCCC)CCCCCCCCC
Formula	C50H97N3O4
M.Wt	804.34
Purity	>95% by ELSD-HPLC
Storage	-20
Shipping condition	Contact us for current shipping conditions
Product classification	Cationic/Ionizable Lipids; Ionizable Lipids for Gene Editing; Ionizable Lipids for brain-targeted delivery; Ionizable Lipids for lung-targeted delivery

Published LC-1 formulation compositions

Component order: LC-1 / DOPE / cholesterol / DMG-PEG2000 (mol%).

Delivery route	LC-1	DOPE	Cholesterol	DMG-PEG2000
Intravenous; liver	30	30	39.5	0.5
Intratracheal; lung	30	30	39.5	0.5
Intrathecal; brain	60	30	8	2

Screening cargo5.7-kb ABE–NanoLuc mRNA

Genome-editing cargoCas9 mRNA + sgRNA

ModelAi9 reporter mice

Published in vivoEdited hepatocytes, IV79.1%

Published in vivoEdited neurons, IT48.3%

Published in vivoEdited astrocytes, IT45.3%

ReferenceDong S, et al. Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing. Nature Biotechnology (2026). doi:10.1038/s41587-026-03298-8. Formulations and editing results: Fig. 2 and accompanying text.

SDSMSDSAvailable upon requestRequest document →

COACOABatch-specific certificateRequest document →

DATADatasheetProduct information pageRead online →

Laboratory planning

Solution Calculators

Molecular weight is prefilled from the cited synthesis record. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	12.4326 mL	2.4865 mL	1.2433 mL
25 mg	31.0814 mL	6.2163 mL	3.1081 mL
50 mg	62.1628 mL	12.4326 mL	6.2163 mL
100 mg	124.3255 mL	24.8651 mL	12.4326 mL
250 mg	310.8138 mL	62.1628 mL	31.0814 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

Request the current batch-specific storage and transport instructions when ordering LC-1.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.