LC-1 (DCL0004)

Ionizable lipid for large RNA and genome-editing delivery research.

Molecular formula: C50H97N3O4. Molecular weight: 804.34 g/mol.

Literature-reported formulations

Liver/lung: LC-1 / DOPE / cholesterol / DMG-PEG2000 = 30 / 30 / 39.5 / 0.5 mol%. Brain: 60 / 30 / 8 / 2 mol%.

Reference

Dong S, et al. Nature Biotechnology (2026). doi:10.1038/s41587-026-03298-8. Structure and characterization: Supplementary Information, LC-lipid-1 and Table 5.

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