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Adjuvant molecules / QS-21
QS-21 chemical structure
CAT. NO. DCAP008Featured

QS-21

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Ships from ShanghaiFor research use only
Product overview

Description & Application

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].

CAS No.141256-04-4
Chemical NameQS-21
SynonymsQS-21;QS-21 ADJUVANT;b-D-Glucopyranosiduronic acid, (3b,4a,16a)-28-[[O-D-apio-b-D-furanosyl-(1®3)-O-b-D-xylopyranosyl-(1®4)-O-6-deoxy-a-L-mannopyranosyl-(1®2)-4-O-[5-[[5-(a-L-arabinofuranosyloxy)-3-hydroxy-6-methyl-1-oxooctyl]oxy]-3-hydroxy-6-methyl-1-oxooctyl]-6-deoxy-b-D-galactopyranosyl]oxy]-16-hydroxy-23,28-dioxoolean-12-en-3-ylO-b-D-galactopyranosyl-(1®2)-O-[b-D-xylopyranosyl-(1®3)]-;(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[(2S,3R,4S,5R,6R)-3-[(2S,3R,4S,5R,6S)-5-[(2S,3R,4R,5R)-5-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3,4-dihydroxy-tetrahydropyran-2-yl]oxy-3,4-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-5-[5-[5-[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-6-methyl-octanoyl]oxy-3-hydroxy-6-methyl-octanoyl]oxy-4-h;QA 21;QA 21V1;QS 21;QS-21-Api;Saponin QA 21V1;CL130;β-D-Glucopyranosiduronic acid, (3β,4α,16α)-28-[[O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-4-O-[5-[[5-(α-L-arabinofuranosyloxy)-3-hydroxy-6-methyl-1-oxooctyl]oxy]-3-hydroxy-6-methyl-1-oxooctyl]-6-deoxy-β-D-galactopyranosyl]oxy]-16-hydroxy-23,28-dioxoole...
SMILES[C@@]12(CCC(C)(C)C[C@]1([H])C1=CCC3[C@@]4(C)CC[C@H](O[C@@H]5O[C@@H]([C@@H](O)[C@H](O[C@H]6OC[C@@H](O)[C@H](O)[C@H]6O)[C@H]5O[C@H]5[C@H](O)[C@H]([C@@H](O)[C@@H](CO)O5)O)C(=O)O)[C@@](C)(C=O)[C@]4([H])CC[C@@]3(C)[C@]1(C)C[C@H]2O)C(=O)O[C@H]1O[C@H]([C@@H](O)[C@@H](OC(=O)CC(O)CC(C(C)CC)OC(=O)CC(O)CC(C(C)CC)O[C@H]2[C@H](O)[C@@H](O)[C@H](CO)O2)[C@@H]1O[C@@H]1O[C@H]([C@H](O[C@H]2OC[C@@H](O)[C@H](O[C@H]3OC[C@](O)(CO)[C@H]3O)[C@H]2O)[C@@H](O)[C@H]1O)C)C
FormulaC92H148O46
M.Wt1990.13195514679
Purity>98%, Standard References Grade
Storage4°C for 1 year, -20°C for more than 2 years
Shipping conditionShips from Shanghai; packaging confirmed at order.
PublicationNot available
Product classificationAdjuvant Molecules
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
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C₁V₁ = C₂V₂
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Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg5.0248 mL1.0050 mL0.5025 mL
25 mg12.5620 mL2.5124 mL1.2562 mL
50 mg25.1240 mL5.0248 mL2.5124 mL
100 mg50.2479 mL10.0496 mL5.0248 mL
250 mg125.6198 mL25.1240 mL12.5620 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
Ships from Shanghai. Storage: 4°C for 1 year, -20°C for more than 2 years
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.