KRN-7000(S34)
DC67239
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MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
| CAS No. | 256373-96-3 |
| Chemical Name | MCC950 sodium |
| Synonyms | CP-456773 sodium;CRID3 sodium salt;MCC-950 sodium;CP456773 sodium;CRID-3 sodium salt |
| SMILES | CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+] |
| Formula | C20H23N2NaO5S |
| M.Wt | 426.4618 |
| Purity | 98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | 1. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55. |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 23.4488 mL | 4.6898 mL | 2.3449 mL |
| 25 mg | 58.6219 mL | 11.7244 mL | 5.8622 mL |
| 50 mg | 117.2438 mL | 23.4488 mL | 11.7244 mL |
| 100 mg | 234.4876 mL | 46.8975 mL | 23.4488 mL |
| 250 mg | 586.2190 mL | 117.2438 mL | 58.6219 mL |
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