E6742 (E6742) is a potent, selective, dual TLR7/8 inhibitor with binding Kd of 1.7 uM/37 nM in ITC assays, respectively, inhibits TLR7/8 agonist CL097 induced reporter activation with IC50 values of 22, 68, and 3.0 nM for hTLR7, mTLR7, and hTLR8, respecti
| CAS No. | 1700609-11-5 |
| Chemical Name | E6742 |
| Synonyms | Not available |
| SMILES | O=C([C@H]1CN(C2=C3C=CC=NC3=C(C#N)C=C2)C[C@@H](C)O1)N[C@H]4CNC[C@H]4F |
| Formula | C20H22FN5O2 |
| M.Wt | 383.43 |
| Purity | Not available |
| Storage | Not available |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 26.0804 mL | 5.2161 mL | 2.6080 mL |
| 25 mg | 65.2009 mL | 13.0402 mL | 6.5201 mL |
| 50 mg | 130.4019 mL | 26.0804 mL | 13.0402 mL |
| 100 mg | 260.8038 mL | 52.1608 mL | 26.0804 mL |
| 250 mg | 652.0095 mL | 130.4019 mL | 65.2009 mL |
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