CU-CPT17e shows strong NF-κB activation in TLR3, TLR8 and TLR9 HEK293 cells with EC50 values of 4.80±0.73, 13.5±0.58 and 5.66±0.17 μM, respectively. CU-CPT17e significantly improves the activity with 13.9±0.9 fold of NF-κB activation and an EC50 value of 4.8±0.7 μM. CU-CPT17e inhibits the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. The induction of apoptosis by CU-CPT17e in HeLa cells is investigated. HeLa cells are cultured with increasing concentrations of CU-CPT17e or poly I:C or blank control (DMSO) for 24 h. Treatment with CU-CPT17e for 24 h at different concentrations (10 to 40 μM) results in an elevation of apoptotic cell population ranging from 10% to 17%, which is more effective than poly I:C at 5 μg/mL. These results suggest that the antiproliferative activity of CU-CPT17e against HeLa cells might result from its ability to directly induce apoptosis[1].
| CAS No. | 2109805-75-4 |
| Chemical Name | CU-CPT17e |
| Synonyms | Not available |
| SMILES | O=[N+](C1=CC=C(COC2C(OCC3C=CC([N+](=O)[O-])=CC=3)=CC3OC4(CCOCC4)C=CC=3C=2)C=C1)[O-] |
| Formula | C27H24N2O8 |
| M.Wt | 504.49 |
| Purity | Not available |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 19.8220 mL | 3.9644 mL | 1.9822 mL |
| 25 mg | 49.5550 mL | 9.9110 mL | 4.9555 mL |
| 50 mg | 99.1100 mL | 19.8220 mL | 9.9110 mL |
| 100 mg | 198.2200 mL | 39.6440 mL | 19.8220 mL |
| 250 mg | 495.5500 mL | 99.1100 mL | 49.5550 mL |
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