D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2.
| CAS No. | 2230218-36-5 |
| Chemical Name | D18 |
| Synonyms | Not available |
| SMILES | Not available |
| Formula | C21H28N6 |
| M.Wt | 364.49 |
| Purity | Not available |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 27.4356 mL | 5.4871 mL | 2.7436 mL |
| 25 mg | 68.5890 mL | 13.7178 mL | 6.8589 mL |
| 50 mg | 137.1780 mL | 27.4356 mL | 13.7178 mL |
| 100 mg | 274.3559 mL | 54.8712 mL | 27.4356 mL |
| 250 mg | 685.8899 mL | 137.1780 mL | 68.5890 mL |
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