Enpatoran (M5049) is an orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran can block both innate and adaptive autoimmunity. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran (M5049) can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran (M5049) inhibits cytokine release, causing great potency in pharmacokinetic/pharmacodynamic properties.
| CAS No. | 2101938-42-3 |
| Chemical Name | Enpatoran free base |
| Synonyms | Not available |
| SMILES | N#CC(C=C1)=C(N=CC=C2)C2=C1N3C[C@@H](C(F)(F)F)C[C@@H](N)C3 |
| Formula | C16H15F3N4 |
| M.Wt | 320.319 |
| Purity | >98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 31.2189 mL | 6.2438 mL | 3.1219 mL |
| 25 mg | 78.0472 mL | 15.6094 mL | 7.8047 mL |
| 50 mg | 156.0944 mL | 31.2189 mL | 15.6094 mL |
| 100 mg | 312.1888 mL | 62.4378 mL | 31.2189 mL |
| 250 mg | 780.4720 mL | 156.0944 mL | 78.0472 mL |
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