For research use only. We do not sell to patients.
Adjuvant molecules / CU-115
CU-115 chemical structure
CAT. NO. DC42507Featured

CU-115

Pack size & price

USD
TotalUS$650
Ships from ShanghaiFor research use only
Product overview

Description & Application

CU115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU 115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells.

CAS No.2471982-20-2
Chemical NameCU-115
SynonymsCU-115
SMILESO=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F
FormulaC21H11F7InO2
M.Wt569.21
Purity>98%
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
Shipping conditionShips from Shanghai; packaging confirmed at order.
Publication1. Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244.
Product classificationAdjuvant Molecules
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg17.5682 mL3.5136 mL1.7568 mL
25 mg43.9205 mL8.7841 mL4.3921 mL
50 mg87.8410 mL17.5682 mL8.7841 mL
100 mg175.6821 mL35.1364 mL17.5682 mL
250 mg439.2052 mL87.8410 mL43.9205 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
Ships from Shanghai. Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.