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Adjuvant molecules / GSK2245035
GSK2245035 chemical structure
CAT. NO. DC28386Featured

GSK2245035

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Ships from ShanghaiFor research use only
Product overview

Description & Application

GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma.

CAS No.1207629-49-9
Chemical NameGSK2245035
SynonymsGSK2245035;5L3SX16QBQ;GTPL9254;LFMPVTVPXHNXOT-HNNXBMFYSA-N;SB19815;compound 32 [PMID: 26861551];J3.609.218A;(S)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8H-purin-8-one;6-amino-2-[(2S)-pentan-2-yloxy]-9-[5-(piperidin-1-yl)pentyl]-8,9-dihydro-7H-purin-8-one;6-amino-2-{[(1S)-1-methylbutyl]oxy}-9[5-(1-piperidinyl) pentyl]-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-7;8H-Purin-8-one, 6-amino-7,9-dihydro-2-((1S)-1-methylbutoxy)-9-(5-(1-piperidinyl)pentyl)-;6-amino-2-[(2S)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7H-purin-8-one;GSK-2245035;HY-118250;F3409-0744;AKOS032954203;DA-63925;compound 32 (PMID: 26861551);6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one;6-amino-7,9-dihydro-2-[(1S)-1-methylbutoxy]-9-[5-(1-piperidinyl)pentyl]-8H-purin-8-one;6-amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl) pentyl]-7,9-dihydro-8H-purin-8-one;G16656;CHEMBL4297492;SCHEMBL565847;NSC-853260;GLXC-15811;UNII-5L3SX16QBQ;CS-0065520;6-amino-2-((1-methylbutyl)oxy)-9-(5-(1-piperidinyl)pentyl)-7,9-dihydro-8H-purin-8-one;MS-26512;1207629-49-9;NSC853260
SMILESO(C1N=C(C2=C(N=1)N(C(N2)=O)CCCCCN1CCCCC1)N)[C@@H](C)CCC
FormulaC20H34N6O2
M.Wt390.522964000702
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Shipping conditionShips from Shanghai; packaging confirmed at order.
PublicationNot available
Product classificationAdjuvant Molecules
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
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C₁V₁ = C₂V₂
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Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg25.6067 mL5.1213 mL2.5607 mL
25 mg64.0167 mL12.8033 mL6.4017 mL
50 mg128.0334 mL25.6067 mL12.8033 mL
100 mg256.0669 mL51.2134 mL25.6067 mL
250 mg640.1672 mL128.0334 mL64.0167 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
Ships from Shanghai. Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.