A selective TLR8 agonist that induces activation of NF-κB at 0.4 uM; induces similar cytokine profiles from human PBMC compared with TLR8 agonist ssRNA; effectively stimulates IL-12 production from mDC, but not pDC; induces TNF-α and IL-12 at 0.1 uM from monocytes and monocyte-derived DC (Mo-DC).
| CAS No. | 256922-53-9 |
| Chemical Name | 2-propylthiazolo[4,5-c]quinolin-4-amine |
| Synonyms | CL075;CL-075;3M002 |
| SMILES | NC1=NC2=CC=CC=C2C(S3)=C1N=C3CCC |
| Formula | C13H13N3S |
| M.Wt | 243.33 |
| Purity | >98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 41.0965 mL | 8.2193 mL | 4.1096 mL |
| 25 mg | 102.7411 mL | 20.5482 mL | 10.2741 mL |
| 50 mg | 205.4823 mL | 41.0965 mL | 20.5482 mL |
| 100 mg | 410.9645 mL | 82.1929 mL | 41.0965 mL |
| 250 mg | 1027.4113 mL | 205.4823 mL | 102.7411 mL |
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