KRN-7000(S34)
DC67239
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Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release.
| CAS No. | 1359993-59-1 |
| Chemical Name | N-{4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy]butyl}octadecanamide |
| Synonyms | MEDI 9197;3M 052 |
| SMILES | NC1C2N=C(N(OCCCCNC(=O)CCCCCCCCCCCCCCCCC)C=2C2C(=CC=CC=2)N=1)CCCC |
| Formula | C36H59N5O2 |
| M.Wt | 593.885969400406 |
| Purity | >98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | 1. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12. |
| Product classification | Adjuvant Molecules |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 16.8382 mL | 3.3676 mL | 1.6838 mL |
| 25 mg | 42.0956 mL | 8.4191 mL | 4.2096 mL |
| 50 mg | 84.1912 mL | 16.8382 mL | 8.4191 mL |
| 100 mg | 168.3825 mL | 33.6765 mL | 16.8382 mL |
| 250 mg | 420.9562 mL | 84.1912 mL | 42.0956 mL |
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