Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH). The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Mipomersen sodium) that retains the same biological activity.
| CAS No. | 1000120-98-8 |
| Chemical Name | Mipomersen |
| Synonyms | ISIS 301012 free base |
| SMILES | Not available |
| Formula | C230H324N67O122P19S19 |
| M.Wt | 7177.14645999996 |
| Purity | >95% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | siRNA/ASOs/Aptamer drugs |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 1.3933 mL | 0.2787 mL | 0.1393 mL |
| 25 mg | 3.4833 mL | 0.6967 mL | 0.3483 mL |
| 50 mg | 6.9666 mL | 1.3933 mL | 0.6967 mL |
| 100 mg | 13.9331 mL | 2.7866 mL | 1.3933 mL |
| 250 mg | 34.8328 mL | 6.9666 mL | 3.4833 mL |
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