ALC-0159 (di-C18) is an analog of ALC-0159, in which the original C14 chain is replaced with C18 chain. C18-ALC-0159 demonstrates high stability in vivo, effectively prevents binding with proteins such as ApoE, and achieves a prolonged blood circulation time. It also reduces liver targeting and accumulation.
| CAS No. | 1849616-42-7 |
| Chemical Name | ALC-0159 (di-C18) |
| Synonyms | ALC-0159;ALC 0159;ALC0159 |
| SMILES | O=C(N(CCCCCCCCCCCCCCC)CCCCCCCCCCCCCC)COCCOC |
| Formula | (C2H4O)NC31H63NO2 |
| M.Wt | 2400.24 |
| Purity | 98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | PEGylated lipids |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 4.1663 mL | 0.8333 mL | 0.4166 mL |
| 25 mg | 10.4156 mL | 2.0831 mL | 1.0416 mL |
| 50 mg | 20.8313 mL | 4.1663 mL | 2.0831 mL |
| 100 mg | 41.6625 mL | 8.3325 mL | 4.1663 mL |
| 250 mg | 104.1563 mL | 20.8313 mL | 10.4156 mL |
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