ARO-AAT is a second-generation RNAi drug. ARO-AAT consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade AAT mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes.
| CAS No. | 2175009-08-0 |
| Chemical Name | Fazirsiran |
| Synonyms | ARO-AAT |
| SMILES | Not available |
| Formula | Not available |
| M.Wt | 15587.60 |
| Purity | >95% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | siRNA/ASOs/Aptamer drugs |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 0.6415 mL | 0.1283 mL | 0.0642 mL |
| 25 mg | 1.6038 mL | 0.3208 mL | 0.1604 mL |
| 50 mg | 3.2077 mL | 0.6415 mL | 0.3208 mL |
| 100 mg | 6.4154 mL | 1.2831 mL | 0.6415 mL |
| 250 mg | 16.0384 mL | 3.2077 mL | 1.6038 mL |
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