For research use only. We do not sell to patients.
siRNA, ASO & aptamer drugs / Nusinersen
Nusinersen chemical structure
CAT. NO. DC47280Featured

Nusinersen

Pack size & price

USD
TotalUS$1,200
Ships from ShanghaiFor research use only
Product overview

Description & Application

Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.

CAS No.1258984-36-9
Chemical NameNusinersen
SynonymsNusinersen;ISIS SMNRx;ISIS-SMN(Rx);Nusinersen [USAN:INN];5Z9SP3X666;RNA, (2'-0-(2-methoxyethyi))(p-thio)(m5u-c-a-c-m5u-m5u-m5u-c-a-m5ua- a-m5 u-g-c-m5u-g-g)
SMILESS=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(N)=NC=NC2=3)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(C)=C2)=O)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(NC(N)=NC2=3)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(N=C(C(C)=C2)N)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(C)=C2)=O)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(NC(N)=NC2=3)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(NC(N)=NC2=3)=O)O1)OCCOC)O)=S)=S)=S)=S)=S)=S)O[C@@H]1[C@@H](COP(O)(O[C@@H]2[C@@H](COP(O)(O[C@@H]3[C@@H](COP(O)(O[C@@H]4[C@@H](COP(O)(O[C@@H]5[C@@H](COP(O)(O[C@@H]6[C@@H](COP(O)(O[C@@H]7[C@@H](COP(O)(O[C@@H]8[C@@H](COP(O)(O[C@@H]9[C@@H](COP(O)(O[C@@H]%10[C@@H](COP(O)(O[C@@H]%11[C@@H](CO)O[C@H]([C@@H]%11OCCOC)N%11C(NC(C(C)=C%11)=O)=O)=S)O[C@H]([C@@H]%10OCCOC)N%10C(N=C(C(C)=C%10)N)=O)=S)O[C@H]([C@@H]9OCCOC)N9C=NC%10C(N)=NC=NC9=%10)=S)O[C@H]([C@@H]8OCCOC)N8C(N=C(C(C)=C8)N)=O)=S)O[C@H]([C@@H]7OCCOC)N7C(NC(C(C)=C7)=O)=O)=S)O[C@H]([C@@H]6OCCOC)N6C(NC(C(C)=C6)=O)=O)=S)O[C@H]([C@@H]5OCCOC)N5C(NC(C(C)=C5)=O)=O)=S)O[C@H]([C@@H]4OCCOC)N4C(N=C(C(C)=C4)N)=O)=S)O[C@H]([C@@H]3OCCOC)N3C=NC4C(N)=NC=NC3=4)=S)O[C@H]([C@@H]2OCCOC)N2C(NC(C(C)=C2)=O)=O)=S)O[C@H]([C@@H]1OCCOC)N1C=NC2C(N)=NC=NC1=2
FormulaC234H340N61O128P17S17
M.Wt7127.1942691803
Purity>95%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Shipping conditionShips from Shanghai; packaging confirmed at order.
PublicationNot available
Product classificationsiRNA/ASOs/Aptamer drugs
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg1.4031 mL0.2806 mL0.1403 mL
25 mg3.5077 mL0.7015 mL0.3508 mL
50 mg7.0154 mL1.4031 mL0.7015 mL
100 mg14.0308 mL2.8062 mL1.4031 mL
250 mg35.0769 mL7.0154 mL3.5077 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
Ships from Shanghai. Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.