CHEMS
DC67625
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HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE, has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs.
| CAS No. | 1027801-73-5 |
| Chemical Name | HAPC-Chol |
| Synonyms | HAPC Chol;(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (3-((2-hydroxyethyl)amino)propyl)carbamate hydroiodide |
| SMILES | C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCCNCCO)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.I |
| Formula | C33H59IN2O3 |
| M.Wt | 658.75 |
| Purity | >98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Shipping condition | Ships from Shanghai; pack and transport conditions confirmed at order. |
| Publication | Not available |
| Product classification | Sterol lipids |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 15.1803 mL | 3.0361 mL | 1.5180 mL |
| 25 mg | 37.9507 mL | 7.5901 mL | 3.7951 mL |
| 50 mg | 75.9013 mL | 15.1803 mL | 7.5901 mL |
| 100 mg | 151.8027 mL | 30.3605 mL | 15.1803 mL |
| 250 mg | 379.5066 mL | 75.9013 mL | 37.9507 mL |
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