DC Chemicals · Product datasheet

PTC299 · DC12482

PTC299 (Emvododstat) is a DHODH inhibitor for pyrimidine metabolism and hematological-cancer research.

ParameterValue
Chemical Name4-chlorophenyl (S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate
CAS No.1256565-36-2
SynonymsPTC-299; PTC 299
FormulaC25H20Cl2N2O3
M.Wt467.34
SMILESN1C2=C(CCN([C@@H]2C2C=CC(OC)=CC=2)C(=O)OC2C=CC(Cl)=CC=2)C2C=C(C=CC1=2)Cl
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

PTC299 (Emvododstat) is a DHODH inhibitor for pyrimidine metabolism and hematological-cancer research.

View referenced In Vitro and In Vivo results on the product page

References

  1. Cao L, et al. Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties. Molecular cancer therapeutics (2019).

Available packs

  • 5 mg · US$500
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