DC Chemicals · Product datasheet

MK-8722 · DC12020

MK-8722 is a direct allosteric activator of mammalian AMPK complexes for metabolic signaling and glucose-homeostasis research.

ParameterValue
Chemical Name(3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
CAS No.1394371-71-1
SynonymsMK-8722,MK8722,MK 8722,1394371-71-1
FormulaC24H20ClN3O4
M.Wt449.89
SMILESClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5
PurityOn request
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

MK-8722 is a direct allosteric activator of mammalian AMPK complexes for metabolic signaling and glucose-homeostasis research.

View referenced In Vitro and In Vivo results on the product page

References

  1. Myers RW, et al. Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. Science (New York, N.Y.) (2017).

Available packs

  • 100 mg · US$850
  • 250 mg · US$1,350
  • 1 g · US$2,700
  • 10 mM * 1 mL in DMSO · US$220
View product and biological activity →

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