DC Chemicals · Product datasheet

Praliciguat · DC11526

Praliciguat is an sGC stimulator for nitric-oxide/cGMP signaling, renal inflammation and fibrosis research.

ParameterValue
Chemical Name1,1,1,3,3,3-hexafluoro-2-{[(5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-yl)amino]methyl}propan-2-ol
CAS No.1628730-49-3
SynonymsIW-1973; IW1973
FormulaC21H14F8N6O2
M.Wt534.37
SMILESC(F)(F)(F)C(CNC1C(F)=CN=C(C2C=C(C3C=CON=3)N(CC3=CC=CC=C3F)N=2)N=1)(O)C(F)(F)F
PurityOn request
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

Praliciguat is an sGC stimulator for nitric-oxide/cGMP signaling, renal inflammation and fibrosis research.

View referenced In Vitro and In Vivo results on the product page

References

  1. Liu G, et al. Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells. American journal of physiology. Renal physiology (2020).

Available packs

  • 100 mg · US$900
  • 250 mg · US$1,600
  • 1 g · US$3,300
  • 10 mM * 1 mL in DMSO · US$220
View product and biological activity →

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