DC Chemicals · Product datasheet
CLP257 · DC11507
CLP257 is a neuronal chloride-signaling research compound originally reported as a KCC2 enhancer. Subsequent work challenged direct KCC2 activation and reported GABAA receptor potentiation.
| Parameter | Value |
|---|---|
| Chemical Name | (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone |
| CAS No. | 1181081-71-9 |
| Synonyms | CLP-257 |
| Formula | C14H14FN3O2S |
| M.Wt | 307.34 |
| SMILES | S1/C(=C\C2=CC=C(F)C=C2O)/C(=O)N=C1N1NCCCC1 |
| Purity | On request |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity summary
CLP257 is a neuronal chloride-signaling research compound originally reported as a KCC2 enhancer. Subsequent work challenged direct KCC2 activation and reported GABAA receptor potentiation.
View referenced In Vitro and In Vivo results on the product pageReferences
- Cardarelli RA, et al. The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity. Nature medicine (2017).
- Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nature medicine (2013).
Available packs
- 100 mg · US$550
- 250 mg · US$900
- 1 g · US$1,800
- 10 mM * 1 mL in DMSO · US$220