DC Chemicals · Product datasheet

Elafibranor(GFT505) · DC10727

Elafibranor (GFT505) is a dual PPARα/δ agonist used in hepatic lipid metabolism, inflammation and fibrosis research.

ParameterValue
Chemical NameElafibranor
CAS No.923978-27-2
SynonymsGFT505; elafibranor E; GFT-505; Elafibranor(GFT505); Elafibranor; Elafibranor [USAN]; 2J3H5C81A5; Elafibranor (USAN); (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-enyl)phenoxy)-2-methylpropanoic acid; Elafibranor [INN]; GFT 505; 2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid; BCP19067; s3720; DB05187; SB16790; (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid; 2-{2,6-dimethyl-4-[(1E)-3-[4-(methylsulfanyl)phenyl]-3-oxoprop-1-en-1-yl]phenoxy}-2-methylpropanoic acid; SureCN815512; S; 2-[2,6-Dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methylpropanoic acid (ACI); (E)-1-[4-(Methylthio)phenyl]-3-[3,5-dimethyl-4-[(carboxydimethylmethyl)oxy]phenyl]prop-2-en-1-one
FormulaC22H24O4S
M.Wt384.488565444946
SMILESO(C1C(C)=CC(/C=C/C(C2C=CC(SC)=CC=2)=O)=CC=1C)C(C)(C)C(=O)O
PurityOn request
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

Elafibranor (GFT505) is a dual PPARα/δ agonist used in hepatic lipid metabolism, inflammation and fibrosis research.

View referenced In Vitro and In Vivo results on the product page

References

  1. Liu L, et al. The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model. PloS one (2020).

Available packs

  • 100 mg · US$550
  • 250 mg · US$750
  • 1 g · US$1,350
  • 10 mM * 1 mL in DMSO · US$220
View product and biological activity →

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