DC Chemicals · Product datasheet

Laropiprant · DC1009

Laropiprant is a DP1 receptor antagonist for prostanoid signaling and platelet-function research. Its effects on platelet activation vary with agonist and concentration.

ParameterValue
Chemical NameLaropiprant
CAS No.571170-77-9
SynonymsMK-0524 Laropiprant; Laropiprant; 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid; Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl) methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)-; MK 0524; MK-0524; (3R)-[4-(4-chlorobenzyl)-7-fluoro-5-(methane-sulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid; [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid; [(3R)-4-(4-chlorophenyl)methyl-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl]acetic acid; [14C]-Laropiprant; Cardaptive; (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid
FormulaC21H19ClFNO4S
M.Wt435.89600
SMILESO=C(O)C[C@H]1CCC2=C1N(CC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4S(=O)(C)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

Laropiprant is a DP1 receptor antagonist for prostanoid signaling and platelet-function research. Its effects on platelet activation vary with agonist and concentration.

View referenced In Vitro and In Vivo results on the product page

References

  1. Philipose S, et al. Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation. PloS one (2012).

Available packs

  • 100 mg · US$650
  • 250 mg · US$1,100
  • 1 g · US$2,400
  • 10 mM * 1 mL in DMSO · US$150
View product and biological activity →

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