DC Chemicals · Product datasheet

Soticlestat · DC11101

Soticlestat is a cholesterol 24-hydroxylase inhibitor used in cholesterol turnover and neuronal-excitability research.

ParameterValue
Chemical NameSoticlestat
CAS No.1429505-03-2
SynonymsSoticlestat; Soticlestat (USAN); Soticlestat [USAN]; 1766MU795L; Soticlestat [INN]; Soticlestat [USAN:INN]; OV935; WHO 10844; D11590; (4-benzyl-4-hydroxypiperidin-1-yl)(2,4'-bipyridin-3-yl)methanone; (4-benzyl-4-hydroxypiperidin-1-yl) (2,4'-bipyridin-3-yl)methanone
FormulaC23H23N3O2
M.Wt373.4476
SMILESO([H])C1(C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])C([H])([H])C([H])([H])N(C(C2C([H])=C([H])C([H])=NC=2C2C([H])=C([H])N=C([H])C=2[H])=O)C([H])([H])C1([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

Soticlestat is a cholesterol 24-hydroxylase inhibitor used in cholesterol turnover and neuronal-excitability research.

View referenced In Vitro and In Vivo results on the product page

References

  1. Hawkins NA, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice. Epilepsia (2021).

Available packs

  • 1g · US$1,950
  • 250mg · US$1,100
  • 100 mg · US$600
  • 10 mM * 1 mL in DMSO · US$220
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