DC Chemicals · Product datasheet
MRL871 · DC11047
MRL871 (MRL-871) is an allosteric RORγt ligand used in nuclear-receptor research. Independent work also identified PPARγ partial agonism.
| Parameter | Value |
|---|---|
| Chemical Name | 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid |
| CAS No. | 1392809-08-3 |
| Synonyms | MRL871; MRL-871; MRL 871 |
| Formula | C22H12ClF3N2O3 |
| M.Wt | 444.794 |
| SMILES | C(O)(=O)C1=CC=C(C2C3=C(N(C(=O)C4=C(C(F)(F)F)C=CC=C4Cl)N=2)C=CC=C3)C=C1 |
| Purity | >98% |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity summary
MRL871 (MRL-871) is an allosteric RORγt ligand used in nuclear-receptor research. Independent work also identified PPARγ partial agonism.
View referenced In Vitro and In Vivo results on the product pageReferences
- Scheepstra M, et al. Identification of an allosteric binding site for RORγt inhibition. Nature communications (2015).
- Indazole MRL-871 interacts with PPARγ via a binding mode that induces partial agonism. Bioorganic & medicinal chemistry (2022).
Available packs
- 5mg · US$450