DC Chemicals · Product datasheet

Anle138b · DC10168

Anle138b is an aggregation-modulating research compound studied in α-synucleinopathies. Published mouse data connect reduced oligomer burden with neuronal and motor outcomes.

ParameterValue
Chemical NameAnle138b
CAS No.882697-00-9
SynonymsAnle138b; Anle-138b; 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole; 5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole; Anle 138b; CID 44608289; BCP32558; Anle138b, >=98% (HPLC); NSC805132; s6782; DB13927; 3-(1,3-Benzodioxole-5-yl)-5-(3-bromophenyl)-1H-pyrazole; 3-(Benzo[d][1,3]dioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
FormulaC16H11BrN2O2
M.Wt343.1747
SMILESBrC1=C([H])C([H])=C([H])C(=C1[H])C1C([H])=C(C2C([H])=C([H])C3=C(C=2[H])OC([H])([H])O3)N([H])N=1
PurityOn request
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

Anle138b is an aggregation-modulating research compound studied in α-synucleinopathies. Published mouse data connect reduced oligomer burden with neuronal and motor outcomes.

View referenced In Vitro and In Vivo results on the product page

References

  1. Lemos M, et al. Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance. Translational neurodegeneration (2020).

Available packs

  • 100 mg · US$400
  • 250 mg · US$800
  • 1 g · US$1,600
  • 10 mM * 1 mL in DMSO · US$150
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