CAT. NO. DCA0008
LC-MG-9
LC-MG-9 is the para-methyl phenyl analogue of LC-MG-1 in an infigratinib-derived FGFR2-degradation series. In the same KATO III Western-blot screen at 1 µM for 12 h, its FGFR2-depletion effect was weaker than that of LC-MG-1. It is a comparative research compound for phenyl-handle structure–activity studies.
Pack sizes, price, purity, stock and lead time: please inquire.
Request a quote / synthesis assessmentPublished cellular evidence
Reported assay conditions
KATO III cells; 1 µM; 12 h; FGFR2 Western blot; DMSO control.
Reported result
LC-MG-9 is the para-methyl phenyl analogue of LC-MG-1 in an infigratinib-derived FGFR2-degradation series. In the same KATO III Western-blot screen at 1 µM for 12 h, its FGFR2-depletion effect was weaker than that of LC-MG-1. It is a comparative research compound for phenyl-handle structure–activity studies.
Source locations: Main Fig. 2A–B; sections 2.3
A compound-specific DC50, antiproliferative IC50, E3-ligase mechanism and in vivo efficacy were not established for this analogue in the cited study.
For research use only. Published findings depend on the reported experimental conditions and do not guarantee product performance. No clinical use.
Identity and specifications
| CAT. NO. | DCA0008 |
|---|---|
| Molecular formula | C35H35Cl2N7O5 |
| Molecular weight | 704.62 |
| Stereochemistry | E alkene; no stereocentres |
| Chemical form | Neutral parent; no counterion assigned |
| SMILES | COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(N4CCN(C(=O)/C=C/C(=O)c5ccc(C)cc5)CC4)cc3)ncn2)c1Cl |
Molecular formula and average molecular weight are calculated from the source-verified structure; molecular weight unit: g/mol.
References
Cao X, Huang X, Song C, Shi S, Zhu Y, Zheng L, Liang G, Chen L. Converting FGFR inhibitors into selective covalent molecular glue degraders via transposable gluing handles. European Journal of Medicinal Chemistry 316 (2026), 119034. doi:10.1016/j.ejmech.2026.119034.
Source locations: Main Fig. 2A–B; experimental compound LC-MG-9, p. 10; supplied SI section 13.
Published online: 2 June 2026.