CAT. NO. DCA0006
LC-MG-1
LC-MG-1 is an infigratinib-derived research compound with an E-configured phenyl enone handle. It was identified as an initial FGFR2-degradation hit in KATO III cells at 1 µM for 12 h and used as the starting scaffold for the phenyl-handle structure–activity study.
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Reported assay conditions
KATO III cells; 1 µM; 12 h; FGFR2 Western blot; DMSO control.
Reported result
LC-MG-1 is an infigratinib-derived research compound with an E-configured phenyl enone handle. It was identified as an initial FGFR2-degradation hit in KATO III cells at 1 µM for 12 h and used as the starting scaffold for the phenyl-handle structure–activity study.
Source locations: Main Fig. 1C–D and 2A–B; sections 2.2 and 2.3
A compound-specific DC50, antiproliferative IC50, E3-ligase mechanism and in vivo efficacy were not established for this analogue in the cited study.
For research use only. Published findings depend on the reported experimental conditions and do not guarantee product performance. No clinical use.
Identity and specifications
| CAT. NO. | DCA0006 |
|---|---|
| Molecular formula | C34H33Cl2N7O5 |
| Molecular weight | 690.59 |
| Stereochemistry | E alkene; no stereocentres |
| Chemical form | Neutral parent; no counterion assigned |
| SMILES | COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(N4CCN(C(=O)/C=C/C(=O)c5ccccc5)CC4)cc3)ncn2)c1Cl |
Molecular formula and average molecular weight are calculated from the source-verified structure; molecular weight unit: g/mol.
References
Cao X, Huang X, Song C, Shi S, Zhu Y, Zheng L, Liang G, Chen L. Converting FGFR inhibitors into selective covalent molecular glue degraders via transposable gluing handles. European Journal of Medicinal Chemistry 316 (2026), 119034. doi:10.1016/j.ejmech.2026.119034.
Source locations: Main Fig. 1C–D and 2A–B; experimental compound LC-MG-1, p. 9; supplied SI section 5.
Published online: 2 June 2026.