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PA97MD101
Datasheet
Product identity and specifications
| Item | Information |
|---|---|
| Product | PA97MD101 |
| Catalog number | DCL0011 |
| CAS No. | Not available |
| Molecular formula | C52H107N5O4 |
| Molecular weight | 866.46 |
| Purity specification | >95% by ELSD-HPLC |
Product description
Product overview Description & Application PA97MD101 is an ester-containing ionizable lipid with a tetraethylenepentamine-derived headgroup and two branched hydrophobic ester arms. Identified through machine-learning-guided screening and independent animal validation, its LNPs produced approximately fourfold higher hepatic luciferase expression than SM-102 in mice after intravenous Fluc mRNA delivery at 0.1 mg/kg. The study also demonstrated Cre-dependent liver recombination and Cas9/sgTtr-mediated TTR suppression. Formulation-dependent activity was associated with acidic-pH membrane activity and reduced lysosomal colocalization. PA97MD101 is a preclinical research candidate for hepatic mRNA and CRISPR cargo delivery. Primary literature: Zhang Z, Ren Y, Kong D, et al. Interpretable AI-guided discovery of degradable ionizable lipids with enhanced hepatic mRNA delivery in vivo. Nature Communications (2026), Article in Press. Read paper ↗ RNA Delivery Gene-editing delivery Cationic and ionizable lipids Featured lipid products Liver delivery
Formulation and performance
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Ordering
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