DC67558 · Updated 28 October 2026
AMG1541
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 0.5607 mL | 0.2804 mL |
| 25 mg | 1.4018 mL | 0.7009 mL |
| 50 mg | 2.8037 mL | 1.4018 mL |
| 100 mg | 5.6073 mL | 2.8037 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| AMG1541 | DC67558 | 1783.38 | 35 | 0.624183 |
| DOPE | DC33634 | 744.03 | 16 | 0.119045 |
| Cholesterol | DCD-041 | 386.65 | 46.5 | 0.179792 |
| DMG-PEG2000 | DC40169 | 2507 | 2.5 | 0.062675 |
AMG1541/DOPE/cholesterol/DMG-PEG2000 = 35:16:46.5:2.5 mol%. Ionizable lipid:mRNA = 10:1 by weight; the authors separately report N/P = 11.4:1. Source: Supplementary Table 1 (PDF p. 3). Component-mass calculations use the catalog molecular weights shown here; the reported N/P is not recalculated from them.
Read the complete study conditions, biological results, tolerability and figures →