DC67558 · Updated 28 October 2026

AMG1541

Product Datasheet

AMG1541 is a degradable cyclic amino alcohol ionizable lipid studied for intramuscular mRNA delivery and influenza vaccine research. Its reported LNP formulation increased local reporter expression and antibody responses relative to the tested SM-102 formulation, while reducing liver reporter expression.

CAS No.	Not available
Chemical Name	AMG1541
Synonyms	AMG-1541，AMG 1541
SMILES	CCCCCC/C=C\CCCC(=O)OCC(O)CN1CCN(CC(O)COC(=O)CCC/C=C\CCCCCC)CCN(CC(O)COC(=O)CCC/C=C\CCCCCC)CCN(CC(O)COC(=O)CCC/C=C\CCCCCC)CCN(CC(O)COC(=O)CCC/C=C\CCCCCC)CCN(CC(O)COC(=O)CCC/C=C\CCCCCC)CC1
Formula	C102H186O18N6
M.Wt	1783.38
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Rudra A, Gupta A, Reed K, et al. Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines. Nature Nanotechnology 20, 1831–1842 (2025). DOI: 10.1038/s41565-025-02044-6. Author manuscript, Figures 2–4 and Supplementary Tables 1/3.

Research evidence

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Specifications are catalog specifications, not batch test results.