Lipid TD5
Instructions for Use
Product information
TD5 is a tryptamine-derived ionizable cationic lipid used to prepare LNPs for mRNA delivery. In the reported formulation, TD5 supported pH-dependent mRNA encapsulation and CNS delivery after intrathecal administration. Reported performance values below remain tied to the stated formulation and study conditions; they should not be compared across methods without reviewing those conditions.
| CAS No. | 2855180-86-6 |
| Chemical Name | Lipid TD5 |
| Formula | C 45 H 81 N 3 O |
| M.Wt | 680.16 g/mol |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Pure lipid, shipped from Shanghai with ice packs. |
Formulation & study context
Literature information refers to the cited study and its particular formulation. Administration routes are research context, not clinical instructions or a guarantee of performance.
| Component | mol% | Role |
|---|---|---|
| TD5 | 50.0 | Ionizable lipid |
| DOPE | 10.0 | Helper phospholipid |
| Cholesterol | 38.5 | Membrane support |
| DMG-PEG2000 | 1.5 | PEG lipid |
| Total | 100.0 |
| N/P ratio | Not reported in accessible source |
| Cargo | mRNA |
| Administration route | Intrathecal injection (IT) |
| Animal model | Mouse |
| Dose | 0.135 mg mRNA/kg |
| Evaluation timepoint | See cited study |
N/P is the molar ratio of specified lipid nitrogen groups to nucleic-acid phosphate groups. A lipid:cargo mass ratio is a different quantity and must not be used as N/P.
Stock-solution preparation table
Calculated from the product-page molecular weight: 680.16 g/mol. Volumes are final solution volumes.
| Lipid mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 14.702 mL | 2.940 mL | 1.470 mL |
| 25 mg | 36.756 mL | 7.351 mL | 3.676 mL |
| 50 mg | 73.512 mL | 14.702 mL | 7.351 mL |
| 100 mg | 147.024 mL | 29.405 mL | 14.702 mL |
| 250 mg | 367.561 mL | 73.512 mL | 36.756 mL |
Volume (mL) = mass (mg) × 1000 / [MW (g/mol) × concentration (mM)]. These are mathematical conversions, not measured solubility or validated solvent recommendations. Confirm solvent compatibility and the molecular weight of the exact material before use.
Open editable solution calculators →Handling & storage
Provided that storage conditions are as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 1 year.
Wherever possible, prepare and use solutions on the same day. If stock solutions must be prepared in advance, store them as aliquots in tightly sealed vials at -20°C. Generally, these will be usable for up to one month.
Before use, and prior to opening the vial, allow the product to equilibrate to room temperature for at least 1 hour.
References
Cited literature for this formulation and performance dataset Xue Y, et al. Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection. Advanced Materials . 2025;37(27):2417097. DOI: 10.1002/adma.202417097 · Read full text