DC Chemicals

DC67521 · Updated 28 October 2026

Lipid TD5

Product Datasheet

TD5 is an ionizable lipid investigated for mRNA delivery to the central nervous system after intrathecal injection. Mouse studies report neuronal and astrocyte expression, Cre-reporter activation and delivery of a CRISPR cargo. These findings concern intrathecal administration rather than intravenous blood-brain-barrier crossing.

Specifications

PropertyValue
CAS No.2855180-86-6
Chemical NameLipid TD5
SynonymsLipid-TD5; TD5; TD-5
SMILESCCCCCCCCCCCCCCN(CCCCCCCCCCCCCC)CCCCCCNC(=O)CCC1=CNC2=CC=CC=C12
FormulaC45H81N3O
M.Wt680.16
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year. In solvent: −80 °C, 6 months; −20 °C, 1 month. Keep sealed and protected from light.
Shipping conditionPure lipid, shipped from Shanghai with ice packs.
Publication
  1. Xue Y, Wang C, Li H, et al. Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection. Advanced Materials 37, 2417097 (2025). DOI: 10.1002/adma.202417097.
  2. Full author manuscript: Figures 2–6.

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.