DC67295 · Updated 28 October 2026
MK16
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.0022 mL | 0.5011 mL |
| 25 mg | 2.5054 mL | 1.2527 mL |
| 50 mg | 5.0108 mL | 2.5054 mL |
| 100 mg | 10.0216 mL | 5.0108 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| MK16 | DC67295 | 997.84 | 60 | 0.457900 |
| DOPE | DC33634 | 744.03 | 30 | 0.170714 |
| Cholesterol | DCD-041 | 386.65 | 40 | 0.118287 |
| DMG-PEG2000 | DC40169 | 2507 | 0.75 | 0.014380 |
MK16/DOPE/cholesterol/DMG-PEG2000 = 60:30:40:0.75 relative molar parts, not mol%. The parts sum to 130.75 and are normalized only for the calculated masses. MK16:mRNA = 12.5:1 by weight; N/P was not disclosed. Source: formulation selection in the main text and Supplementary Fig. 6a.
Read the complete study conditions, biological results, tolerability and figures →