DC Chemicals

DC60782 · Updated 28 October 2026

Lipid A4B4-S3

Product Datasheet

A4B4-S3 is an ionizable lipid studied for mRNA expression, liver Cre-reporter activation and repeated delivery of hEPO mRNA. Published evidence includes an apparent LNP pKa of 6.912, intramuscular reporter comparisons and liver-focused repeat-dose tolerability.

CAS No.Not available
Chemical NameLipid A4B4-S3
SynonymsLipid A4B4 S3
SMILESCCCCCCCC/C=C\CCCCCCCCNC(=O)C(CCCCCOC(=O)C(CCCCCC)CCCCCCCC)OC(=O)CCCN(C)C
FormulaC47H90N2O5
M.Wt763.246
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Xu Y, Gong F, Golubovic A et al. Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery. PNAS 122, e2409572122 (2025). DOI: 10.1073/pnas.2409572122.
  2. Supporting Information: Table S1 and Figs. S11–S14.

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.