DC60509 · Updated 28 October 2026
4A3-SCC-PH
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 0.5133 mL | 0.2567 mL |
| 25 mg | 1.2833 mL | 0.6417 mL |
| 50 mg | 2.5666 mL | 1.2833 mL |
| 100 mg | 5.1332 mL | 2.5666 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| 4A3-SCC-PH | DC60509 | 1948.094 | 15 | 0.463832 |
| DOPE | DC33634 | 744.03 | 15 | 0.177150 |
| Cholesterol | DCD-041 | 386.65 | 30 | 0.184119 |
| DMG-PEG2000 | DC40169 | 2507 | 3 | 0.119381 |
Source: main text and Supporting Information, LNP formulation and pKa sections. The reported 15:15:30:3 values are relative molar parts (sum 63), not mol%. Mass conversion normalizes this sum. The SI describes 40:1 using the ambiguous phrase “weight molar”; it is not treated here as a verified N/P or lipid:RNA mass ratio. DMG-PEG2000 uses MW 2507.
Read the complete study conditions, biological results, tolerability and figures →