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4A3-SCC-PH
Formulation & Performance
Literature-reported formulation composition
| Component | Reported molar ratio | Role |
|---|---|---|
| 4A3-SCC-PH | 15 | Ionizable lipid |
| DOPE | 15 | Helper phospholipid |
| Cholesterol | 30 | Sterol |
| DMG-PEG2000 | 3 | PEG lipid |
| Reported ratio sum | 63 | Original ratio retained |
Component molecular weights and calculated amounts
Composition retained from the cited study below. Research planning aid only. Results cover lipid component weights and do not include RNA, buffer, solvent, process loss or an N/P ratio.
| Component | Molecular weight | Molar parts | Normalized mol% | Amount (µmol) | Weight (mg) |
|---|---|---|---|---|---|
| 4A3-SCC-PH | 23.810 | 25.2091 | 49.1096 | ||
| DOPE | 23.810 | 25.2091 | 18.7564 | ||
| Cholesterol | 47.619 | 50.4181 | 19.4942 | ||
| DMG-PEG2000 | 4.762 | 5.0418 | 12.6398 |
Calculated total: 100.0000 mg lipid.
Calculated catalog planning quantities; RNA, solvent and process loss are excluded. DMG-PEG2000 uses 2507. Component mass = total lipid mass × molar parts × molecular weight / sum(parts × molecular weight). This conversion does not infer N/P.
Literature-reported performance for the cited formulation
Literature-reported176-fold higher0.1 mg/kg FLuc mRNA; mouse IV comparison · 6 hMain PDF pp.4-5, Fig.3
Literature-reported99%0.2 mg/kg Cre mRNA; tdTomato reporter mice; recombination readout · 2 daysMain PDF pp.8-9, Fig.5; SI p.30
Literature Data DisclaimerAll formulation parameters and performance values shown in this section are derived from the cited publication and are provided for reference only. These results were obtained using the specific materials, formulation process, cargo, dose, analytical method, model and administration route described in that study. Unless otherwise stated, the data were not generated or independently verified by DC Chemicals. DC Chemicals supplies the lipid compound only and does not guarantee that customers will reproduce the reported LNP properties or biological performance.
The administration route shown above was used in the cited study and is not a clinical-use instruction or recommendation by DC Chemicals.
The administration route shown above was used in the cited study and is not a clinical-use instruction or recommendation by DC Chemicals.
Cited literature for this formulation and performance datasetchen-et-al-2023-modular-design-of-biodegradable-ionizable-lipids-for-improved-mrna-delivery-and-precise-cancer. DOI: 10.1021/jacs.3c09143 DOI: 10.1021/jacs.3c09143
15:15:30:3 is a molar ratio, not mol%. SI calls 40:1 a "weight molar" ratio without a clear numerator basis; this is not assigned as N/P. Cre reporter activation is not CRISPR indel frequency.
15:15:30:3 is a molar ratio, not mol%. SI calls 40:1 a "weight molar" ratio without a clear numerator basis; this is not assigned as N/P. Cre reporter activation is not CRISPR indel frequency.