DC60509 · Updated 28 October 2026

4A3-SCC-PH

Product Datasheet

4A3-SCC-PH is a biodegradable ionizable lipid investigated for liver-directed mRNA delivery. Published mouse studies report enhanced luciferase expression and extensive Cre-mediated reporter activation in hepatocytes. The detailed evidence includes formulation composition, cellular delivery, liver expression, imaging applications and tolerability.

CAS No.	Not available
Chemical Name	4A3-SCC-PH
Synonyms	4A3-SCC-PH; 4A3 SCC PH; 4A3-SCC PH; 4A3 SCC-PH
SMILES	CN(CCCN(CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCCN(CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O
Formula	C91H171N3O16S12
M.Wt	1948.094
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Chen Z et al. Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. JACS 145, 24302–24314 (2023). DOI: 10.1021/jacs.3c09143. Supporting Information: formulation, cell and animal methods; Figs. S1–S22.

Research evidence

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Specifications are catalog specifications, not batch test results.