DC Chemicals

DC49907 · Updated 28 October 2026

5A2-SC8

Product Datasheet

5A2-SC8 is a degradable dendrimer lipid studied for small-RNA delivery and as the ionizable component of later multicomponent mRNA LNPs. Published evidence includes liver siRNA knockdown and formulation-dependent bone-marrow reporter delivery. Bone-marrow tropism in the later study required an additional covalent lipid or crosslinker.

CAS No.1857341-90-2
Chemical Name5A2-SC8
Synonyms5A2SC8， 5A2 SC8
SMILESN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)(CCNCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCNCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC
FormulaC93H173N5O20S5
M.Wt1841.76
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Zhou K, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. PNAS (2016). DOI: 10.1073/pnas.1520756113.
  2. Lian X, et al. Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Nature Nanotechnology (2024). DOI: 10.1038/s41565-024-01680-8.

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.