All products / DC80295
Ponometrep(BBO-11818)
Pack sizes and prices
| Pack size | Price |
|---|---|
| 100mg | $850 USDRequest a quote / confirm availability → |
| 250mg | $1,350 USDRequest a quote / confirm availability → |
| 1g | $2,800 USDRequest a quote / confirm availability → |
Confirm stock, lead time, shipping and final quotation with our team.
Product overview
BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS), non-covalent pan-KRAS inhibitor (IC50=28-120 nM). BBO-11818 specifically binds to the Switch-II/Helix 3 pocket, disrupts the KRAS:RAF1 interaction by inducing conformational changes, and blocks the MAPK signaling pathway. BBO-11818 exhibits significant anti-tumor activity, which not only inhibits cell proliferation and induces apoptosis, but also drives tumor regression in xenograft models. BBO-11818 produces synergistic effects when combined with Cetuximab, anti-PD-1 antibody or PI3Kα inhibitor. BBO-11818 is used in the research of KRAS mutation-related malignancies such as pancreatic cancer, non-small cell lung cancer and colorectal cancer.
For research use only. Results depend on experimental conditions and do not constitute a performance guarantee.
Identity and specifications
| Catalog number | DC80295 |
|---|---|
| Product name | Ponometrep(BBO-11818) |
| CAS | 2776175-74-5 |
| Molecular formula | C18H19N3O5S |
| Molecular weight | 389.43 |
| Purity | >98% |
| SMILES | Cc1ncc(COc2ccc3oc(C)c(C(=O)N[C@@H](CO)C(N)=O)c3c2)s1 |
Source-listed specifications; the batch COA applies.
Source and product documents
The supplier source is linked below. Contact us for COA, SDS and batch-specific documents.
DC Chemicals — Ponometrep(BBO-11818) (DC80295)