KetalCN111909020A
A structure-first resource for LNP research
Ionizable Lipid Patent & Literature Library
Explore 18,363 distinct structures across patent and literature collections. Browse LNPDB formulations and experiments, and trace each record to its source.
18,363Distinct structures · combined
155Patent publication labels
42LNPDB literature sources
19,528LNPDB experimental records
Custom Lipid Synthesis
DC Chemicals offers custom synthesis for lipids described in patents and scientific publications. Share the patent or publication reference, compound number or structure, and your required quantity and purity. Our team will assess feasibility and provide a quotation and estimated lead time.
One library. Traceable patent and literature sources.
5,637 entries
Click a structure to browse its details, source annotations and patent provenance. Patent and property information is reproduced from the collected records.
AmideUS20100036115A1
AmideUS20100297023A1
KetalCN107879960A
AmideCN102215820A
KetalCN111909020A
EsterCN104640841B
AmideCN102231952A
AmideWO2020252589A1
CarbamateWO2021000041A1
SiloxaneWO2020097520A1
![Chemical structure for 1-[3-[Tris[(4Z)-4-decen-1-yloxy]silyl]propyl]piperidine](/resources/ionizable-lipid-patents/structures/MOL-d816d109ded09747.svg)
EtherWO2021000041A1
Literature structures, formulations & experimental context
Explore LNPDB
Browse structures from 42 studies, with experimental formulations grouped under each lipid. The dataset also retains 269 supplier catalog records, clearly identified when no experimental data are available.
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Experimental filters must match within the same source record. Molecular weights shown in this view are calculated from SMILES; original LNPDB values remain in the details.
Explore the chemistry. Trace the source.
About the patent collection
This collection brings together patent-associated lipid structures for researchers exploring LNP chemistry. Browse molecular structures alongside CAS numbers, molecular formulas, molecular weights, company and institution labels, patent identifiers, source years, and linker annotations. Each entry links to its listed patent publication.
The 8,673 source rows have been consolidated into 5,637 entries representing 5,635 distinct structures. Identical rows appearing in several worksheets are grouped, with every worksheet and row location retained. Structure diagrams are generated from the supplied SMILES, preserving stated stereochemistry and disconnected components. Names, classifications, company labels and year fields reflect the source collection; consult the linked patent document for its original bibliographic information. This is a collected reference set, not an exhaustive or current census of all lipid patents.
KetalAmideCarbamateEtherBenzeneEsterThiocarbamicDisulfideCyclopentaneTetrahydrofuranSiloxaneCarbonate esterThioetherTriazine
Browse the 155 patent publications in this view
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
LNPDB · Source attribution & scope
From published structures to experimental context
What is included
This edition includes all 19,797 records in the author-provided LNPDB CSV: 19,528 experimental records from 42 studies and 269 catalog records. The 12,845 distinct submitted SMILES normalize to 12,837 exact structures. Every source record and all 66 original fields are retained. The LNPDB study collection described in the paper is current to August 2025; its 2026 publication date does not imply coverage of all 2026 studies.
There are 109 exact structure matches with the existing patent collection. Across both collections, this edition contains 18,363 distinct structures. Patent records and literature records retain their own provenance.
How to interpret the data
Different studies use different assays, normalization and dose conventions. Readouts are displayed with their method and experimental context; values should not be used as a universal efficacy ranking. A target label describes the experiment and does not by itself establish organ selectivity. Catalog records have no experimental formulation or delivery result.
Original SMILES, source values and record identifiers are preserved. Structure grouping uses canonical isomeric SMILES without neutralizing charges or assigning missing stereochemistry. This integration has not independently revalidated every structure and assay against its original publication.
Dataset citation: Collins E, Ji J, Kim SG, et al. Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery. Nature Communications 17, 2464 (2026). Read the database paper ↗
Source snapshot: author repository commit fc7c38933b44, retrieved 16 September 2026. Adapted for browsing by DC Chemicals. LNPDB attribution is retained; this page does not imply endorsement by the dataset authors.
Dataset license and attribution
MIT License Copyright (c) 2025 Evan Collins Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.