Datasheet — CQ-12

DCL0019 · Updated 20 October 2026

Description:

CQ-12 (CQ12) is a chloroquine-derived, autophagy-inhibitory lipidoid containing a 7-chloroquinoline headgroup and a hydroxyl-bearing C12 lipid chain. It was selected from the CQ6–CQ18 series for incorporation into autolysosomal degradation-inhibitory lipid nanoparticles (AUDI-LNPs). Replacing 30% of the SM-102 molar fraction with CQ-12 produced a five-component formulation containing 15 mol% CQ-12 and increased luciferase expression approximately 5.3-fold in HEK293T cells under the reported conditions. The study also evaluated CQ-12-substituted MC3 and ALC-0315 formulations, subcutaneous and intravenous mRNA delivery, and local intratracheal delivery. IL-10 and TGF-β mRNA formulations were investigated in mouse models of psoriasis and acute lung injury, respectively. CQ-12 supports research into autophagy-modulating LNPs and cytokine mRNA delivery.

Chemical Information

Parameter	Value
Catalog number	DCL0019
Chemical Name	CQ-12
CAS No.	Not available
Synonyms	CQ12; CQ 12; AUDI-lipidoid CQ12; Chloroquine-C12 lipidoid
Formula	C30H50ClN3O
M.Wt	504.2
SMILES	CCCCCCCCCCC(O)CN(c1ccnc2cc(Cl)ccc12)C(C)CCCN(CC)CC
Purity	>95% by ELSD-HPLC
Storage	Follow the supplied batch label; protect from light and moisture. Compound-specific stock-solution shelf life is not established.
Publication	Zhou T-Q, Sun W, Yang H, Zhang G, Naeem A, Weng Y, Zhu M, Wei Z-Z, Huang Y, Liang X-J. Autolysosomal degradation-inhibitory nanoparticles for enhanced mRNA escape and cytokine therapy. Cell Biomaterials. Article in press (2026), article 100593. doi:10.1016/j.celbio.2026.100593. DOI: 10.1016/j.celbio.2026.100593

Handling Guide

Follow the supplied batch label for storage. Protect the material from light and moisture; allow a sealed vial to equilibrate before opening. Prepare small aliquots and avoid repeated freeze–thaw cycles. Ethanol is used in the published lipid phase; a quantitative CQ-12 solubility limit and stock-solution shelf life are not established.

CQ-12 neat-material and stock-solution shelf life are not established by the cited paper. Follow the supplied batch label.

Formulation & Performance:

The selected SM-102 / CQ-12 / DSPC / cholesterol / DMG-PEG2000 formulation is 35:15:10:38.5:1.5 mol%. N/P is not reported. The source lipidoid/RNA ratio is 20:1 w/w, with the numerator accounting not fully defined. Separate MC3 and ALC-0315 formulations and route-specific results are available in the detailed guide.

Read the component mass table, preparation, experiment-specific results and references →

References:

Zhou T-Q, Sun W, Yang H, Zhang G, Naeem A, Weng Y, Zhu M, Wei Z-Z, Huang Y, Liang X-J. Autolysosomal degradation-inhibitory nanoparticles for enhanced mRNA escape and cytokine therapy. Cell Biomaterials. Article in press (2026), article 100593. doi:10.1016/j.celbio.2026.100593. DOI: 10.1016/j.celbio.2026.100593