Datasheet — DA lipid

DCL0017 · Updated 18 October 2026

Description:

DA lipid is a dopamine-derived ionizable lipid incorporating a catechol antioxidant headgroup, one tertiary amine and two ester-linked branched hydrophobic tails. In the cited study, DA lipid and DA lipid nanoparticles scavenged reactive oxygen species more effectively than their oxidized ODA counterparts. DA LNPs supported higher mRNA-derived protein expression than ODA LNPs in DC2.4 cells and after intramuscular administration in mice, with expression comparable to ALC-0315 LNPs. OVA mRNA-loaded DA LNPs improved antigen presentation and suppressed tumor growth in a prophylactic B16-OVA melanoma model relative to ODA LNPs. These results support research into antioxidant mRNA delivery and preventive cancer vaccination.

Chemical Information

Parameter	Value
Catalog number	DCL0017
Chemical Name	DA lipid
CAS No.	Not available
Synonyms	Dopamine-derived ionizable lipid; Dopamine lipid; DA ionizable lipid
Formula	C52H95NO6
M.Wt	830.33
SMILES	CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCCCOC(=O)C(CCCCCC)CCCCCCCC)CCc1ccc(O)c(O)c1
Purity	>95% by ELSD-HPLC
Storage	−20 °C; unopened, protected from light and moisture. Up to 1 year under the standard catalog guidance; follow the batch expiry/retest date.

Handling:

Store the unopened product at −20 °C, protected from light and moisture, with the vial tightly sealed. The standard storage period is 1 year; follow the expiry or retest date on the supplied batch documentation. Allow the closed vial to reach room temperature before opening to avoid condensation.

We ship the pure lipid with ice packs, without ethanol. Prepare an ethanol stock solution when required. Gentle warming and brief sonication may assist dissolution; confirm complete dissolution at the intended concentration.

Prepare and use solutions on the same day wherever possible. If advance preparation is required, use a validated storage procedure and tightly sealed aliquots. A general solution shelf life is not assigned.

For small amounts of oily or viscous lipid, dissolve the entire pack and take volumetric aliquots. For example, dissolve 25 mg and adjust to a final volume of 1 mL to obtain 25 mg/mL; a 100 µL aliquot contains 2.5 mg.

The catechol-containing DA structure should be protected from unnecessary oxidation. The source does not establish DA-specific long-term stock-solution stability. Standard unopened-product storage guidance is subject to the batch label.

Formulation & Performance:

Reported DA / DSPC / cholesterol / DMG-PEG ratio: 50:10:38.5:1.5 mol%. Intramuscular delivery was evaluated; the B16-OVA study used prophylactic vaccination. The source PEG grade and N/P are not specified.

Read detailed preparation, mass conversion, experimental results and limitations →

References:

Fang G, Tu Z, Feng H, Wu R, Xing Y, Li H, Xiang L, Shi Z, Zhang C, Hao K, Tian H. Design of lipid nanoparticles with potent reactive oxygen species scavenging capacity for efficient mRNA delivery. Nano Research. 2026;19:94909223. doi:10.26599/NR.2026.94909223. Just Accepted, available online 28 September 2026. Supplied file includes the main article and Electronic Supplementary Material, Figs. S1–S29. DOI: 10.26599/NR.2026.94909223