mRNA1 delivery · mouse expression study
Cargo | mRNA1 encoding a CD19/CD3 bispecific antibody
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Lipid 03-135
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
mRNA1 delivery · mouse expression study
Model | NOD/SCID mice
mRNA1 delivery · mouse expression study
Administration | Intravenous (tail vein), single dose
mRNA1 delivery · mouse expression study
Dose | 1 μg mRNA per mouse
mRNA1 delivery · mouse expression study
Comparators | 01-1, 03-208, 02-1 and 02-3
mRNA1 delivery · mouse expression study
N/P ratio | Not reported for this experiment
mRNA1 delivery · mouse expression study
Exact formulation | 03-135 with helper lipids described in Example 2. Component molar percentages and exact PEG-lipid identity are not resolved for Figure 3B.
Reported observation
Serum antibody expression Figure 3B shows the highest plotted mean serum antibody concentrations for the 03-135 formulation at 24 and 48 hours. This is a qualitative comparison of the plotted means; the figure does not report a between-lipid statistical significance test.
Reported observation
Scope of the evidence The result supports intravenous mRNA-encoded antibody delivery research. This patent does not disclose a 03-135-specific subcutaneous or monkey experiment. The antitumor experiment in Figure 4 uses lipid 01-1.